Early endosome antigen 1

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August undefined, 2024

The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1. EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a homodimer … See more EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level. See more Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole. Mycobacterium tuberculosis is known to inhibit the … See more • early+endosome+antigen+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Overview of all the structural … See more • endosome • Phosphatidylinositol 3-phosphate • FYVE domain See more WebMar 5, 2024 · EEA1 early endosome antigen 1 [Homo sapiens (human)] - Gene - NCBI NCBI Skip to main content Skip to navigation Resources All Resources Chemicals & …

EEA1 Antibody (G-4) SCBT - Santa Cruz Biotechnology

WebAutoantibodies to EEA1, an antigen on early endosomes, were first reported in the serum of a patient with subacute cutaneous lupus erythematosus (SCLE). Here we have … WebEEA1 early endosome antigen 1 [ (human)] Gene ID: 8411, updated on 8-Jan-2024 Summary Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding … clover 100 years lyrics

A NanoBiT assay to monitor membrane proteins trafficking for …

WebMar 8, 2024 · d LgBiT-FYVE and Early Endosome Antigen 1. In both cases, secondary antibodies coupled with oligonucleotides (PLA probes) bind to the primary antibodies. When the PLA probes are in close proximity ... WebEarly Endosome Antigen 1. In the case of the EEA1 FYVE domain, the emission of a single conserved tryptophan residue located in the head group binding site is quenched … WebDescription: The monoclonal antibody 1G11 recognizes human, mouse and rat early endosome antigen 1 (EEA1). EEA1 is a hydrophilic peripheral membrane protein found in the cytosol and present on early endosome membranes. EEA1 is a dimer that is localized to early endosomes via a cysteine-rich zinc-finger-like FYVE domain. clover 1099

Rabenosyn-5 defines the fate of the transferrin receptor following ...

WebFeb 1, 2004 · Rab5 together with early endosome antigen 1 (EEA1) 118,119,120 — a phosphoinositide-binding protein — regulate fusion between primary endocytic vesicles and sorting endosomes. More … WebEarly Endosome Antigen 1 Studies of EEA1 have been instrumental in defining the localization of PI(3)P. Closer examination of the protein reveals it is a large coiled-coil protein (Figure 138.3a) that can bind to the GTP-bound form of Rab5, a GTPase required for endosomal membrane fusion [17]. c6 incompatibility\u0027sWeb3 hours ago · Our studies found that CRB3 could colocalize with EEA1-positive early endosomes, CD63-positive late endosomes and Rab11-positive recycling endosomes . In addition, after 2 hours of ... sequentially. Then, antigen retrieval was performed in Tris-EDTA buffer (pH 9.0) heated to 95°C for 20 min. Endogenous peroxidase activity was … c6i.4xlarge specs

"WebEarly endosome antigen 1 (EEA1) is 170-kDa polypeptide required for endosome fusion. EEA1 binds to both phosphtidylinositol 3-phosphate (PtdIns3P) and to Rab5-GTP in … " - Early endosome antigen 1

Early endosome antigen 1

Anti-EEA1 antibody, Mouse monoclonal - Sigma-Aldrich

WebEEA1, early endosome antigen 1 Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog EEA1, early endosome antigen 1. … WebEarly endosome antigen 1 (EEA1) is a 170 kDa coiled-coil protein belonging to a group of early endosomal Rab5 effector proteins. EEA1 has a putative role in the tethering/docking of endocytic vesicles prior to their fusion with early endosomes. This protein is characterized as containing a zinc finger-like domain and coiled-coil regions.

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WebThe endocytic vesicles mature to early endosomes and then the late endosomes by inward budding of the plasma membrane. The late endosomes turn into MVBs by accumulating the intraluminal vesicles ... Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol 2003; … WebJul 10, 2024 · At this stage, ingested materials can be recycled back to the plasma membrane, sent to the trans-Golgi Network (TGN), or degraded through endosomal acidification. Each compartment in the pathway is marked by characteristic proteins, such as early endosome antigen 1 (EEA1), lysosomal-associated membrane protein 1 …

WebSep 2, 2005 · The FYVE domain is defined by the three conserved elements: the N-terminal WxxD, the central RR/KHHCR, and the C-terminal RVC motifs that form the PtdIns(3)P binding site seen in the solution and crystal structures of early endosome antigen 1 (EEA1), Hrs, and Vps27p FYVE (6, 13, 17, 18).The PtdIns(3)P headgroup is coordinated … WebThe FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. Lawe DC, Patki V, Heller-Harrison …

WebThe gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol. WebSep 27, 2016 · Sequence analysis predicted that the 1,411-amino acid EEA1 protein is largely hydrophilic with short amphiphilic regions in the 15 N-terminal amino acids and in segments centered around amino acids 515 and 645. EEA1 contains an N-terminal zinc finger motif, a cys-rich C-terminal metal-binding finger, and multiple sites for N …

WebJan 3, 2024 · EEA1 (early endosome antigen 1) is a peripheral membrane protein that co-localizes with the transferrin receptor and Rab5 on early endosomes. EEA1 contains a calmodulin-binding IQ motif and cysteine rich finger motif necessary for its specific localization to the early endosomes. EEA1 has sequence homology to several yeast …

WebEarly endosome antigen 1 (EEA1) is an early endosomal protein that contains an N-terminal zinc finger motif, a cys-rich C-terminal metal-binding finger, and multiple sites for … clover 102lcWebRab22a is an important small GTPase protein the molecule that is involved in intracellular transportation and regulation of proteins. It also plays an important role in antigens uptake, transportation, regulation of endosome morphology, and also regulates the transport of antigens to MHC (Major Histocompatibility Complex) molecules. To investigate the role … c6i instance typeWebMay 15, 2015 · Following entry into host cells, OMVs migrate to early endosome antigen 1 (EEA1)-labelled endosomes where they interact with and are detected by nucleotide-binding oligomerization domain ... c6 inconsistency\u0027sWebJan 17, 2024 · the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1; F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1), with … clover 101WebEssential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such as … clover 10 standWebDec 14, 2024 · EEA1 (early endosome antigen 1) is a peripheral membrane protein that co-localizes with the transferrin receptor and Rab5 on early endosomes. EEA1 contains … clover 1099-kWebEndosomes are found in three forms: early endosomes, late endosomes, and recycling endosomes. The early endosomes develop into late endosomes, which then fuse with … clover 10q