Web2 de out. de 2024 · In addition to the HIF-1-dependent upregulation of glycolytic enzymes in response to hypoxia, HIF-1α can suppress OXPHOS under hypoxic conditions by … WebThe aerobic glycolysis is closely associated with hypoxic tumor microenvironment. 18 HIF serves as an important transcription factor expressed by malignant cell adapted to anoxic …
Regulatory mechanisms of lncRNAs in cancer glycolysis CMAR
Web7 de jan. de 2024 · Albendazole inhibited growth of NSCLC cells by suppressing HIF-1α-dependent glycolysis and VEGF expression. Albendazole (ABZ) has an anti-tumor ability and inhibits HIF-1α activity. HIF-1α is associated with glycolysis and vascular endothelial cell growth factor (VEGF) expression, which plays an important role in cancer progression. WebThe aerobic glycolysis is closely associated with hypoxic tumor microenvironment. 18 HIF serves as an important transcription factor expressed by malignant cell adapted to anoxic environments. 83 Activating HIF-1α enhances a glycolytic phenotype through promoting transcription of GLUTs or glycolysis-related enzymes. 84 LncRNAs play critical … grand prismatic spring usa
Glycolysis, via NADH‐dependent dimerisation of CtBPs, regulates ...
WebHypoxia-inducible factor (HIF) 1 α is a metabolic regulator that plays an important role in immunologic responses. Previous studies have demonstrated that HIF1 α participates in … WebThe transcription factor HIF-1 plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis Julian J. Lum, 1,2Thi Bui, Michaela Gruber,1 … Web17 de out. de 2012 · In this study, we addressed the reverse possibility of a metabolic control of HIF-1 in tumor cells. We report that lactate, the end-product of glycolysis, inhibits prolylhydroxylase 2 activity and activates HIF-1 in normoxic oxidative tumor cells but not in Warburg-phenotype tumor cells which also expressed lower basal levels of HIF-1α. grand prismatic spring winter