Toxicity thiophenes
Webthiophene, the simplest sulfur-containing aromatic compound, with molecular formula C4H4S, which closely resembles benzene in its chemical and physical properties. It … WebDec 10, 2015 · Drug metabolism of thiophene containing substrates by cytochrome P450s (CYP450) leads to toxic side effects, for example, nephrotoxicity (suprofen, ticlopidine), hepatotoxicity (tienilic acid), thrombotic thrombocytopenic purpura (clopidogrel), and aplastic anemia (ticlopidine).
Toxicity thiophenes
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WebAug 18, 2014 · Abstract. Thiophene is a five-membered, sulfur-containing heteroaromatic ring commonly used as a building block in drugs. It is considered to be a structural alert, … WebThiophenes can act as dienophiles in Diels–Alder reactions with electron-poor dienes such as hexachlorocyclopentadiene, tetrazines, or o -quinone monoimines.
WebPolythiophenes (PTs) are polymerized thiophenes, a sulfur heterocycle.The parent PT is an insoluble colored solid with the formula (C 4 H 2 S) n. The rings are linked through the 2- and 5-positions. Poly(alkylthiophene)s have alkyl substituents at the 3- or 4-position(s). They are also colored solids, but tend to be soluble in organic solvents. . PTs become conductive … Thiophene was discovered as a contaminant in benzene. It was observed that isatin (an indole) forms a blue dye if it is mixed with sulfuric acid and crude benzene. The formation of the blue indophenin had long been believed to be a reaction of benzene itself. Viktor Meyer was able to isolate thiophene as the actual … See more Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like … See more At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. The high reactivity of … See more • Some Thiophenes • Thieno[3,2-b]thiophene, one of the four thienothiophenes. • 2,2'-Bithiophene. See more • International Chemical Safety Card 1190 • Chisholm, Hugh, ed. (1911). "Thiophen" . Encyclopædia Britannica. Vol. 26 (11th ed.). Cambridge University Press. See more Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. The first synthesis of thiophene by Meyer, … See more Thiophene is considered to be aromatic, although theoretical calculations suggest that the degree of aromaticity is less than that of benzene. The … See more Thiophenes are important heterocyclic compounds that are widely used as building blocks in many agrochemicals and pharmaceuticals. The benzene ring of a biologically active … See more
WebNaturally occurring thiophenes possess excellent nematicidal and fungicidal activities. However, thiophenes often have limited application in soil due to their light-dependent toxicity given the living and reproductive condition of soil-borne pathogens. WebThe aim of this work was to evaluate the impact of the thiophene-derived aminophosphonates 1–6 on seedling emergence and growth of monocotyledonous oat (Avena sativa) and dicotyledonous radish (Raphanus sativus L.), and phytotoxicity against three persistent and resistant weeds (Galinsoga parviflora Cav., Rumex acetosa …
WebSep 1, 1991 · The phototoxicity and non-light-mediated toxicity of 41 naturally occurring and synthetic tricyclic thiophenes was assessed against larvae of the mosquito Aedes atropalpus. Seventeen of the...
WebDec 21, 2015 · Abstract Drug metabolism of thiophene containing substrates by cytochrome P450s (CYP450) leads to toxic side effects, for example, nephrotoxicity (suprofen, … the un\\u0027s general guidelines for human rightsWebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. Department of Health and Human Services. the un\\u0027s chief administrative officer is theWebDibenzothiophene C12H8S CID 3023 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... the un-wordWebJul 1, 2014 · ... against Aedes aegypti was reported and the toxic effect increased with the number of thiophene moieties in the molecule. Strong activity was observed for 2'' … the un\\u0027s sdgsWebMar 3, 2024 · Toxicity due to a specific structural alert is highly conditional, depending on the metabolism of the alert, the reactivity of its metabolites, dosage, and competing detoxification pathways. A systems approach, which explicitly models these pathways, could more effectively assess the toxicity risk of drug candidates. the un\\u0027s global communications strategyWebAbstract The occurrence, toxicity, and uses of thiophenes are discussed in order to provide the setting within which analyses must be performed. Measured and calculated properties of thiophenes are given. Chemical and spectroscopic techniques for analysis of thiophenes are discussed and some applications of the techniques are indicated. the un\\u0027s new statueWebFrom these publications, it is noteworthy that the metabolic transformation of thiophenes is a key element of their potential biological activity and potential toxicity through the formation of reactive intermediates (Gramec et al., 2014). the un\\u0027s role in global governance